Table 2.

Comparison of the MICs of MX-2401 at different calcium concentrations against S. aureus, E. faecalis, and E. faecium

OrganismCompoundMIC (μg/ml) ina:Fold decrease in MIC
MHBCAMHBCAMHBc
MSSA (clinical isolate)Daptomycin32NDb0.564
MX-240132132
MRSA (ATCC 43300)Daptomycin32ND0.564
MX-240164232
E. faecium (VSE; clinical isolate)Daptomycin128ND432
MX-240164416
E. faecalis (VSE; ATCC 29212)DaptomycinND32216
MX-2401ND824
VancomycinND11None
  • a MHB, Mueller-Hinton broth; CAMHB, cation-adjusted Mueller-Hinton broth; CAMHBc, cation-adjusted Mueller-Hinton broth supplemented with 25 mg/liter of Ca2+.

  • b ND, not done.