Table 1.

Patient characteristics and daily dose of ethambutol

DP Marais SANTA CentreBrewelskloof HospitalCombined
No. of subjects60129189
Median (range) age (yr)38 (18–64)36 (16–72)36 (16–72)
Median (range) wt (kg)a52 (36–67)46 (29–86)47 (29–86)
Median (range) BMI (kg/m2)a,b19 (15–23)18 (12–36)18 (12–36)
Median (range) serum creatinine level (μmol/liter)77 (48–121)74 (43–174)74 (43–174)
Median (range) creatinine clearance (ml/min)c80 (51–150)78 (23–128)79 (23–150)
Median (range) alkaline phosphatase concn (U/liter)a87 (53–619)73 (39–276)77 (39–619)
Median (range) alanine aminotransferase concn (U/liter)18 (8.0–57)15 (6.0–58)16 (6.0–58)
Median (range) aspartate aminotransferase concn (U/liter)a26 (11–94)18 (9.0–63)22 (9.0–94)
Median (range) total bilirubin concn (μmol/liter)6.0 (1.0–13)6.0 (1.0–33)6.0 (1.0–33)
Median (range) urea concn (mmol/liter)3.7 (2.1–8.5)3.3 (1.9–13)3.5 (1.9–13)
Median (range) serum hemoglobin concn (g/dl)12 (8.2–16)12 (7.4–15)12 (7.4–16)
Median (range) hematocrit (%)37 (25–49)38 (24–47)38 (24–49)
Median (range) mean corpuscular vol (fl)a89 (72–102)93 (62–121)91 (62–121)
Median (range) red blood cell count (1012/liter)4.2 (2.6–5.8)4.2 (2.2–5.7)4.2 (2.2–5.8)
Median (range) white blood cell count (109/liter )a6.8 (1.1–17)8.4 (3.4–26)7.9 (1.1–26)
No. (%) of subjects by sexa
    Male45 (75)57 (44)102 (54)
    Female15 (25)72 (56)87 (46)
No. (%) of subjects by racea,d
    Black15 (25)15 (12)30 (16)
    Colored43 (72)113 (88)156 (83)
    White2 (3)0 (0)2 (1)
No. (%) of subjects with moderate to high alcohol usea47 (78)78 (60)125 (66)
No. (%) of subjects HIV positive12 (20)12 (9.3)24 (13)
No. (%) of subjects receiving daily ethambutol dose (mg) of:
    80031 (52)23 (18)54 (29)
    1,00015 (25)18 (14)33 (17)
    1,20014 (23)87 (67)101 (53)
    1,5000 (0)1 (1)1 (1)
  • a Statistically significant difference between sites at the 95% confidence level.

  • b For the DP Marais SANTA Centre, Brewelskloof Hospital, and combined groups, 5%, 24%, and 18% of the patients, respectively, had BMIs of <16 kg/m2.

  • c Distribution truncated at 150 ml/min.

  • d With respect to race, the proportions of blacks were compared between the two locations.