Parameter^{a} | NONMEM value/bootstrap value^{b} | |
---|---|---|

Estimate | % relative SE^{c} | |

k (h_{a}^{−1}) | 0.474/0.498 | 24/19 |

IIV on k (% CV)_{a} | 39^{d}/43 | 80/61 |

MTT (h) | 0.789/0.770 | 17/18 |

IIV on MTT (% CV) | 93^{e}/90 | 20/22 |

Effect of presence of HIV on F (fractional change) | −0.154/−0.162 | 40/39 |

CL/F (liter/h) | 39.9/39.7 | 3.1/5.9 |

IIV on CL/F (% CV) | 20^{f}/21 | 57/86 |

IOV on CL/F (% CV) | 36/34 | 45/87 |

V_{1}/F (liters) | 82.4/90.0 | 42/29 |

V_{2}/F (liters) | 623/642^{g} | 22/30^{g} |

Q (liters/h) | 34.3/33.8 | 10/7.9 |

Additive residual error (mg/liter) | 0.107/0.104 | 20/29 |

Proportional residual error (% CV) | 31.8/31.6 | 4.4/4.6 |

↵a

*k*, absorption rate constant; MTT, mean transit time;_{a}*V*_{1}/*F*, central volume of distribution;*V*_{2}/*F*, peripheral volume of distribution;*Q*, intercompartmental clearance; CV, coefficient of variation. Typical value of*F*= 1 · (1 − 0.154 × HIV), with HIV being 0 and 1 for negative and positive HIV status, respectively; typical value of CL/*F*= 39.7 · (body weight/50)^{3/4}; typical value of central volume of distribution = 82.4 · (body weight/50); typical value of peripheral volume of distribution = 623 · (body weight/50); typical value of intercompartmental clearance = 34.3 · (body weight/50)^{3/4}.↵b The relative standard errors for bootstrap estimates reported as standard error/median.

↵c For interindividual and interoccasion variability terms, the relative standard errors are given for the corresponding variance term.

↵d Eta shrinkage, 40%.

↵e Eta shrinkage, 22%.

↵f Eta shrinkage, 49%.

↵g One extreme bootstrap estimate (85,500) was excluded; inclusion of this value produces a bootstrap median of 642 (relative standard error, 540%).