Table 3.

Previously reported values of oral clearance of ethambutola

CL/F (liters/h)CL/F) (liters/h/kg)PopulationDosing and samplingCommentsReference
40.30.81Adults with tuberculosis; body wt, 47 kg800, 1,000, or 1,200 mg daily doses; predose and rich and sparse sampling to 8-12 h postdosePresent study
67, 531.05, 0.83Adults with tuberculosis; body wt, 63.5 kg800 mg, single and daily doses; predose and rich sampling to 12 h postdoseValues refer to data following first and repeated doses, respectively13
43, 440.73, 0.75Healthy adults; body wt, 59 kg15 mg/kg, single dose; rich sampling to 24 h postdoseCL/F estimated from individual AUCs and doses; values refer to 2 oral formulations, respectively18
70Not estimatedAdults with tuberculosis; body wt not reported25 mg/kg, daily doses; predose and rich sampling to 8 h postdoseAUC reported; CL/F roughly estimated using mean value of AUC and dose22
901.14Healthy adults; body wt, 79.3 kg25 mg/kg, single dose; rich sampling to 48 h postdoseValues reported refer to model-based analysis27
551.17Adults with tuberculosis; body wt, 47.3 kg750 mg, daily doses; predose and rich sampling to 12 h postdoseAUC reported; CL/F roughly estimated using mean values of AUC, dose, and body wt30
74, 861.10, 1.42Adults with tuberculosis; body wt, 64 kg1,325 mg, daily doses; predose and rich sampling to 10 h postdoseValues reported refer to noncompartmental and model-based analyses, respectively39
  • a CL/F, body weight, and doses are the reported means in the studied populations. Values in italics were not reported in the publications but have been estimated given mean values of AUC, dose, and/or body weight, unless stated otherwise.