Table 2.

Plasma pharmacokinetics of finafloxacin in healthy volunteers after single-dose administration (part A)a

Dose (mg)No. of subjectsCmax (mg/liter)Cmax,norm [(mg/liter)/mg]AUC (h · mg/liter)AUC∞,norm [(h · mg/liter)/mg]tmax (h)t1/2 (h)CL/F (liters/h)Vz/F (liters)
2530.240.00960.420.0171.001.2859.0109
5060.44 ± 0.160.00881.26 ± 0.480.0250.883.8 ± 2.745.0 ± 17.1220 ± 127
10061.32 ± 0.620.0132.80 ± 0.720.0280.507.2 ± 3.237.2 ± 7.5389 ± 202
20061.90 ± 0.730.00954.08 ± 1.050.0200.754.6 ± 1.951.5 ± 11.7348 ± 194
40065.06 ± 2.090.01314.2 ± 4.440.0361.0010.0 ± 4.430.8 ± 10.4487 ± 363
800611.1 ± 2.960.01429.2 ± 7.500.0360.8810.5 ± 2.229.0 ± 7.7435 ± 130
  • a Where indicated, values are means ± standard deviations. Cmax, peak plasma concentration; AUC, area under the concentration-time curve; tmax, time to reach Cmax (for this parameter median values are reported); t1/2 terminal half life; CL/F, total body clearance; Vz/F, distribution volume based on the terminal phase; norm, values normalized by the administered dose per kg of body weight; AUC, AUC extrapolated to infinite time.