Table 3.

Plasma pharmacokinetics of finafloxacin in six healthy volunteers per dose after multiple-dose administration (part B)a

Dose (mg)Day no.Cmax (mg/liter)Cmax,norm [(mg/liter)/mg]AUC24h (h · mg/liter)AUC24h,norm [(h · mg/liter)/mg]tmax (h)t1/2 (h)CL/F (liters/h)Vz/F (liters)
15011.69 ± 0.380.0113.76 ± 0.820.0250.50
15071.50 ± 0.520.0104.01 ± 0.640.0270.505.3 ± 0.637.4 ± 5.8282 ± 25
30012.96 ± 0.880.00998.75 ± 3.500.0291.50
30074.15 ± 2.110.0149.09 ± 3.830.0300.636.5 ± 2.537.4 ± 17.5337 ± 155
60017.67 ± 3.420.01318.7 ± 7.630.0310.75
60076.76 ± 2.200.01119.2 ± 6.400.0320.888.8 ± 3.132.5 ± 10.2409 ± 175
80018.68 ± 1.960.01120.8 ± 7.420.0260.75
80078.95 ± 3.110.01126.1 ± 8.600.0330.8814.0 ± 5.531.6 ± 10.6659 ± 467
  • a Where indicated, values are means ± standard deviations. AUC24h, area under the plasma concentration-time curve to 24 h after dosing. For the explanation of other symbols, see the footnote to Table 2.