Table 2.

Posaconazole pharmacokinetic parameters in plasma and toenails after multiple oral posaconazole once daily for 12 or 24 weeksa

POS treatmentValue for:Mean ratio (CV%)bValue for other toenails
PlasmaGreat toenaila
No. of patientsCmin, ng/mlNo. of patientsCmax, ng/gTmax,c wksNo. of patientsCmax, ng/gTmax,c wks
100 mg, 24 wks33270 (60)331,100 (51)36 (12, 48)2.04 (82)351,440 (54)32 (4, 48)
200 mg, 24 wks33626 (76)342,130 (70)42 (2, 48)1.28 (81)342,890 (64)32 (2, 48)
400 mg, 24 wks30776 (50)322,140 (82)38 (2, 48)2.92 (136)322,590 (58)30 (4, 48)
400 mg, 12 wks28616 (71)302,750 (70)42 (20, 48)NA334,210 (137)28 (4, 48)
  • a Cmax, maximum observed posaconazole concentration; Cmin, minimum observed posaconazole concentration; NA, not available; POS, posaconazole; Tmax, time to maximum observed posaconazole concentration. Cmin and Cmax are expressed as means (CV%).

  • b Mean posaconazole concentration ratio between great toenail and plasma at week 24.

  • c Median (range).