Table 7

Cell wall thickness of pair CB5011/CB5012 and mutant derivatives

StrainCell wall thickness (nm)DAP MIC (μg/ml)Relevant genotype and phenotype
CB501123.1 ± 1.10.5DS
CB501233.2 ± 1.5a4.0DR
MAR-425.4 ± 1.1b0.5CB5012 + ΔmprF::cat
MAR-525.3 ± 1.3b0.75MAR-4 + pMPRF-1 (wild type)
MAR-635.5 ± 1.42.0MAR-4 + pMPRF-2 (mutant)
MAR-724.5 ± 1.1b0.25CB5012 ΔvraSR::cat
MAR-831.3 ± 1.13.0MAR-7 + pVRASR-2
  • a Significantly higher than DS CB5011 (P < 0.01).

  • b Significantly lower than DR CB5012 (P < 0.01).