Table 2

MICs of recombinants with either the P216L or F219I substitution compared to those of the recipient isolate and the transformation control isolate

IsolateBase change in cyp51AaMIC (μg/ml)
Codon 216Codon 219ITCVRCPOS
Transformation recipient isolateCCCTTT0.50.50.063
Transformation controlCCCTTT0.50.50.063
Recombinant P216LCTCTTT>160.51
Recombinant F219ICCCATT>160.51
  • a Bold indicates the base change.