Parameter^{a} | Result | ||
---|---|---|---|

Mean | Median | SD | |

K (h_{a}^{−1}) | 9.77 | 3.85 | 10.30 |

V_{max} (mg/h) | 37.67 | 37.38 | 11.19 |

K (mg/liter)_{m} | 2.07 | 2.28 | 1.11 |

Vol (liter) | 149.11 | 76.65 | 173.49 |

K_{cp} (h^{−1}) | 2.01 | 0.44 | 3.33 |

K_{pc} (h^{−1}) | 9.35 | 2.14 | 11.68 |

F | 0.86 | 0.91 | 0.13 |

Lag (h) | 1.12 | 0.77 | 0.99 |

↵a

*K*is the first-order rate constant that connects the gut with the central compartment,_{a}*V*_{max}is the maximum rate of enzyme activity of voriconazole,*K*is the concentration of voriconazole where clearance is half maximal,_{m}*K*_{cp}and*K*_{pc}are the first-order intercompartmental rate constants connecting the central and peripheral compartments,*F*is the bioavailability, and Lag is the absorption time.