Table 2

Nonsynonymous mutations observed in ED43/SG-neo(G) replicon clones

Replicon cloneNucleotide mutationaAmino acid substitutionbNS proteinc
12989 (4631) GT1431 D→YNS3
22989 (4631) GA1431 D→NNS3
32804 (4446) CA1369 T→KNS3
42804 (4446) CA1369 T→KNS3
52623 (4265) GC1309 A→A/PNS3
3373 (5015) GC1559 E→QNS3
62375 (4017) CG1226 A→GNS3
  • a Positions within the ED43 subgenomic replicon and within the full-length ED43 genome are given (with the latter given in parentheses).

  • b The position within the full-length ED43 polyprotein is given.

  • c NS, nonstructural.