Table 2

In vivo activities of anidulafungin, caspofungin, and micafungin against wild-type C. glabrata isolates in a neutropenic murine disseminated candidiasis model

Antifungal agent and C. glabrata isolate no.MIC (μg/ml)Static dose (mg/kg/24 h)1-log kill (mg/kg/24 h)AUCf/MIC based on:
Static dose1-log kill
Anidulafungin
    CG 5700.031.973.7212.623.8
    CG 55920.063.5711.811.437.5
    CG 5130.062.454.137.8313.2
    CG 336090.032.004.2112.626.9
    CG 329300.061.583.315.0010.6
    CG 353150.256.40NAb4.92NA
    CG 53760.036.807.5040.447.7
    CG 343410.126.90NA11.0NA
Meana0.083.965.7813.226.6
Median0.063.014.1711.225.4
SD0.072.353.3111.414.2
Caspofungin
    CG 5700.120.170.211.391.72
    CG 55920.030.120.163.945.25
    CG 5130.030.080.142.624.59
    CG 336090.030.060.101.973.28
    CG 329300.030.000.020.100.49
    CG 353150.120.071.030.578.45
    CG 53760.030.170.325.5810.5
    CG 343410.250.030.860.123.38
Meana0.080.090.352.044.71
Median0.030.080.191.683.99
SD0.080.060.381.953.35
Micafungin
    CG 55920.021.805.468.4025.0
    CG 5130.021.34NA6.20NA
    CG 336090.020.411.401.906.5
    CG 329300.010.291.522.6614.2
    CG 353150.062.403.772.804.33
    CG 53760.012.674.0023.034.5
    CG 343410.062.184.262.514.9
Meana0.031.583.406.7814.9
Median0.021.803.892.8010.3
SD0.020.951.617.5412.4
  • a Statistically significant comparisons included the anidulafungin versus caspofungin static dose free drug AUC/MIC and the 1-log kill free drug AUC/MIC P = 0.003 and 0.004, respectively).

  • b NA, pharmacodynamic endpoint was not achieved.