Table 3

In vivo activities of anidulafungin, caspofungin, and micafungin against fks mutant C. glabrata isolates in a neutropenic murine disseminated candidiasis model

Antifungal agent and C. glabrata isolate no.MIC (μg/ml)Static dose (mg/kg/24 h)1-log kill (mg/kg/24 h)AUCf/MIC based on:
Static dose1-log kill
Anidulafungin
    CG 47470.061.31NAa4.19NA
    CG 47204NANANANA
    CG 1095615.69NA1.09NA
    CG 7294NANANANA
    CG 143782NANANANA
    CG 211118.8NA3.59NA
    CG 760134.9NA7.77NA
    CG 20920.503.3811.21.304.29
    CG 47420.253.4517.62.6513.5
    CG 336161NANANANA
    CG 376612NANANANA
Meanb1.5311.314.43.438.87
Median1.004.5714.43.128.87
SD1.3613.24.532.456.49
Caspofungin
    CG 474710.250.430.250.42
    CG 4720814.9NA1.06NA
    CG 1095622.3820.31.175.20
    CG 72916NANANANA
    CG 143784NANANANA
    CG 21114.2624.84.1911.1
    CG 76017.4752.45.8115.6
    CG 209210.360.810.360.79
    CG 474210.322.400.312.36
    CG 336160.252.086.648.1922.1
Meanb3.534.0115.42.678.21
Median1.002.236.641.125.20
SD4.955.0619.03.038.30
Micafungin
    CG 47470.251.121.770.310.49
    CG 47204NANANANA
    CG 109560.250.222.630.060.73
    CG 7298NANANANA
    CG 143782NANANANA
    CG 2110.254.83NA1.33NA
    CG 7600.254.24NA1.17NA
    CG 20920.130.942.650.521.47
    CG 47420.501.3010.280.181.36
    CG 336160.253.887.891.12.2
    CG 376610.259.2520.602.55.2
Meanb1.473.227.640.901.91
Median0.252.595.270.811.41
SD2.472.997.200.811.72
  • a NA, not achieved.

  • b There was not a statistical difference between the median static dose or 1-log kill free drug AUC/MIC target endpoint for any of the three drugs.