Table 1

MICs of selected antituberculosis compounds against M. tuberculosis H37Rv and corresponding interaction profiles with BTZ043 assessed by REMA checkerboard

CompoundMIC (μg/ml) by REMAInteraction profile with BTZ043
ΣFICOutcome
BTZ0430.0015
Rifampin0.00151.0Additive
Isoniazid0.21.0Additive
Ethambutol0.61.0Additive
TMC2070.080.5Synergistic
PA-8240.151.0Additive
Moxifloxacin0.0251.0Additive
Meropenem20.75Additive
Meropenem plus clavulanate0.50.75Additive
SQ-1090.1751.0Additive