Table 3

Frequencies of spontaneous staphylococcal strain resistance to AFN-1252 and linezolid

StrainMIC (μg/ml)MIC multipleResistance frequency
AFN-1252LinezolidAFN-1252Linezolid
S. aureus 29213 MSSA0.008246.6E-10<5.8E-10
128<3.3E-10<5.8E-10
S. aureus 43300 MRSA0.008242.4E-09<4.3E-10
128<3.0E-10<4.3E-10
S. aureus 2293 CA-MRSA0.008448.6E-10<4.4E-11
84.6E-10<4.4E-11
16<6.6E-10<4.4E-11
S. aureus 1137 HA-MRSA0.00844<6.6E-10<6.6E-10
86.6E-10<6.6E-10
16<6.6E-10<6.6E-10
S. aureus 2012 VISA MRSA0.008141.4 × E-9<1.1E-10
84.0E-10<1.1E-10
163.3E-10<1.1E-10
S. aureus 1725 LinR MRSA0.008>3249.0E-09Not done
84.0E-10Not done
166.6E-10Not done
S. epidermidis 1024939 MSSE0.008242.1E-09<2.9E-10
128<1.1E-09<2.9E-10