Table 2

Antimicrobial peptides used in this study

PeptideSequenceFCharge (pH 7)cHydrophilic vol (Å)dReferencee
HH18IWVIWRR-NH2a3965.1Unpublished
CP10AILAWKWAWWAWRR-NH241,255.111
IndolicidinILPWKWPWWPWRR-NH241,027.336
HH2VQLRIRVAVIRA-NH241,317.6Unpublished
HH17KIWVRWK-NH24980.4Unpublished
PleurocidinGWGSFFKKAAHVGKHVGKAALTHYL41,938.08a
Bac2ARLARIVVIRVAR-NH251,169.942
Polymyxin Bfa-BTB(BBFDLBBT)b5305.941
Colistinfa-BTB(BBLDLBBT)51,144.841
IDR-1002VQRWLIVWRIRK-NH251,269.830
IDR-1012IFWRRIVIVKKF-NH251,147.9Unpublished
IDR-1018VRLIVAVRIWRR-NH251,072.138
HHC36KRWWKWWRR-NH261,426.44
IDR-1010IRWRIRVWVRRI-NH261,431.1Unpublished
IDR-1020VRLRIRWWVLRK-NH261,398.4Unpublished
CP29KWKSFIKKLTTAVKKVLTTGLPALIS61,329.912
CRAMPGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ62,908.113
CP26KWKSFIKKLTSAAKKVVTTAKPLISS71,362.112
CP28KWKLFKKIGIGAVLKVLTTGLPALKLTK71,145.432
  • a Sequence in the one-letter amino acid code; NH2 indicates the amidation of the carboxyl terminus.

  • b Sequence in the one-letter amino acid code; B indicates positively charged α,γ-diaminobutyrate; a superscript D indicates that amino acid is the d-enantiomer; fa indicates a 6-methyloctanoyl or 6-methylheptanoyl fatty acid chain.

  • c Sum of formal charges, descriptor 83 (FCharge) calculated using MOE software.

  • d Hydrophilic volume, descriptor 247 (vsurf_W3).

  • e Unpublished, R. E. W. Hancock and K. Hilpert, unpublished data.