Table 6

Fitness costs of Myx-resistant mutants after 0, 1, and 2 serial passages

RNAP subunit and mutationaNo. of serial passagesFitness cost (% per generation [± SEM])
β 1080 (1275) Val → Ile08 (±2)
19 (±1)
29 (±1)
β¢ 334 (345) Lys → Asn06 (±2)
16 (±1)
28 (±1)
  • a Residues are numbered as in S. aureus RNAP and, in parentheses, as in E. coli RNAP.