Table 1

Clofazimine and amikacin susceptibility in rapidly growing mycobacteria

SpeciesNo. of isolatesaClofazimine MIC (μg/ml)Amikacin MIC (μg/ml)No. eligible for synergy testingb% of tests revealing synergy (no. of isolates with synergistic result/total no. eligible for testing)Clofazimine-amikacin combination MICs (μg/ml)
MIC50MIC90MIC50MIC90
M. abscessus subsp. abscessus342≤0.51.016.032.06882 (56/68)≤0.5/2.0 (MIC50), 1.0/2.0 (MIC90)
M. abscessus subsp. bolletii48≤0.51.08.032.0967 (6/9)≤0.5/2.0
M. chelonae57≤0.51.08.016.0580 (4/5)≤0.5/2.0
M. fortuitum44≤0.5≤0.5≤2.0≤2.01100 (1/1)≤0.5/2.0
  • a Only results for 491 isolates of the 3 most frequent species are given; see text for results for the remaining 73 isolates of 16 species.

  • b Isolates were eligible for synergy testing if the clofazimine MIC was >0.5 μg/ml and the amikacin MIC was >2.0 μg/ml (see the text).