Parameter | Estimated value | % RSE |
---|---|---|

TV(CL/F)_{STD} (liters · h^{−1}) | 10.0 | 3.7 |

TV(V/F)_{STD} (liters) | 86.7 | 2.3 |

MTT (h) | 0.713 | 1.6 |

No. of transit compartments | 1 FIX | 1 FIX |

E_{max} | 1.04 | 2.6 |

EC_{50} (mg · liter^{−1}) | 0.0705 | 6.3 |

k (h_{ENZ}^{−1}) | 0.00369 | 5.6 |

CL-V correlation (%) | 91.1 | 20.7 |

(Ffat)_{CL/}_{F} | 0.311 | 40.2 |

(Ffat)_{V/F} | 0.188 | 49.1 |

IIV_{CL/} (%)_{F} | 30.0 | 12.3 |

IIV (%)_{V/F} | 19.2 | 14.8 |

IIV_{EC50} (%) | 493.0 | 19 |

IOV_{MTT} (%) | 68.0 | 7 |

IOV (%)_{F} | 16.2 | 11.2 |

V/F-HIV (%) | 29.6 | 17.2 |

Additive error (mg · liter^{−1}) | 0.965 | 2.8 |

Proportional error (%) | 9.9 | 4.7 |

↵a IIV, interindividual variability expressed as a coefficient of variation; IOV, interoccasion variability expressed as a coefficient of variation; RSE, relative standard error reported on the approximate standard deviation scale; TV(CL/

*F*)_{STD}, the typical oral clearance at the preinduced state in a patient weighing 70 kg; TV(*V/F*)_{STD}, the typical apparent volume of distribution in a patient weighing 70 kg; MTT, mean transit time;*E*_{max}, maximal increase in the enzyme production rate; EC_{50}, rifampin concentration at which half the*E*_{max}is reached;*k*, rate constant for first-order degradation of the enzyme pool; CL-_{ENZ}*V*correlation, correlation between CL/*F*and*V/F*; (*Ffat*)_{CL/}, estimated contribution of fat-free mass and body weight to CL/_{F}*F*; (*Ffat*), estimated contribution of fat-free mass and body weight to_{V/F}*V/F*;*V/F*-HIV, increase in apparent volume of distribution in HIV-infected patients; 1 FIX, number of transit compartments fixed to 1.