Parameter^{b} | CL/F (liters/h) | V/_{C}F (liters) | Q_{1}/F (liters/h) | V_{P}_{1}/F (liters) | Q_{2}/F (liters/h) | V_{P}_{2}/F (liters) | MTT (h) | No. of transit comp. | F (%) | σ | Pregnancy covariate effect (%) on: | |
---|---|---|---|---|---|---|---|---|---|---|---|---|

CL | F | |||||||||||

Population estimate (% RSE) | 60.2 (10.5) | 3,070 (12.5) | 427 (14.9) | 4,440 (17.8) | 160 (10.7) | 31,400 (9.55) | 2.04 (4.97) | 5 (fixed) | 100 (fixed) | 0.285 (5.47) | 45.0 (24.5) | 46.8 (35.6) |

95% CI for population estimate | 49.6–74.2 | 2,400–3,930 | 324–575 | 3,210–6,300 | 131–196 | 26,500–38,300 | 1.85–2.25 | 0.255–0.314 | 25.1–69.1 | 18.2–86.0 | ||

% CV for IIV/BOV (% RSE) | 21.5 (27.0) | 39.5 (35.7) | 33.8 (28.8) | 45.8 (22.1)^{c} | 56.3 (25.6)^{c} | |||||||

95% CI for IIV/BOV | 14.5–26.2 | 21.7–50.7 | 21.8–42.9 | 35.4–56.1 | 41.8–72.2 |

↵a Data are for 24 pregnant and 24 nonpregnant women. CL, elimination clearance;

*V*, central volume of distribution;_{C}*Q*, intercompartment clearance;*V*, peripheral volume of distribution; MTT, mean absorption transit time; no. of transit comp., number of transit compartments;_{P}*F*, oral bioavailability; σ, additive residual error; IIV, interindividual variability; BOV, between-occasion variability.↵b Population estimates are computed population mean values from NONMEM Relative standard error (RSE) was assessed by the nonparametric bootstrap method (

*n*= 1,000 iterations, of which 848 minimized successfully) of the final pharmacokinetic model. RSE is calculated as 100 × (standard deviation/mean value). The 95% confidence interval (CI) is displayed as the 2.5 to 97.5 percentile of bootstrap estimates. Coefficient of variation (% CV) for interindividual variability and between-occasion variability were calculated as SQRT of [exp(estimated variance) − 1], where SQRT is the square root.↵c Between-occasion variability.