Group | CL/F (liters/h/kg) | V/_{D}F (liters/kg) | t_{1/2} (days) | T_{max} (h) | C_{max} (ng/ml) | AUC_{0-92} (μg · h/ml) | Predicted concn (ng/ml) | |
---|---|---|---|---|---|---|---|---|

Day 7 | Day 28 | |||||||

Total | 1.30 (0.955–1.66) | 664 (492–912) | 20.2 (17.4–24.1) | 3.06 (2.62–4.05) | 244 (173–344) | 25,300 (19,600–32,400) | 28.1 (20.5–34.2) | 10.3 (8.61–14.7) |

Pregnant | 1.28 (0.955–1.59) | 529 (464–708) | 17.5 (16.2–19.4) | 3.14 (2.84–3.84) | 291 (194–362) | 27,400 (21,000–32,400) | 28.8 (23.6–34.6) | 10.3 (9.18–14.4) |

Nonpregnant | 1.32 (0.987–1.85) | 829 (655–1,110) | 24.0 (22.0–26.1) | 3.04 (2.36–4.13) | 216 (139–276) | 23,400 (17,400–35,100) | 22.7 (17.6–32.8) | 10.3 (8.06–14.9) |

P value | 0.599 | <0.001 | <0.001 | 0.421 | 0.035 | 0.49 | 0.085 | 0.893 |

↵a Data are for 24 pregnant and 24 nonpregnant women. Post hoc estimates were calculated as median values (interquartile ranges) from empirical Bayes estimates, and statistical differences were estimated with a nonparametric Mann-Whitney test. CL, elimination clearance;

*F*, oral bioavailability;*V*, apparent total volume of distribution (_{D}*V*/_{C}*F*+*V*_{P}_{1}/*F*+*V*_{P}_{2}/*F*);*t*_{1/2}, terminal elimination half-life;*T*_{max}, predicted time to peak concentration;*C*_{max}, predicted peak concentration; AUC_{0-92,}area under the concentration-time curve from time point 0 to day 92.