Parameter^{b} | CL/F (liters/h) | V/F (liters) | MTT (h) | No. of transit comp. | F (%) | σ | Covariate effect on F (%) | |
---|---|---|---|---|---|---|---|---|

Pregnancy | Parasitemia | |||||||

Population estimate (% RSE) | 78.0 (7.00) | 129 (7.30) | 0.982 (5.30) | 7 (fixed) | 100 (fixed) | 0.580 (5.11) | −37.5 (17.2) | 27.8 (12.7) |

95% CI for population estimate | 67.4–88.6 | 111–149 | 0.890–1.09 | 0.523–0.634 | 24.0–49.0 | 21.3–37.3 | ||

% CV for IIV/BOV (% RSE) | 12.8 (27.7) | 50.9 (15.7)^{c} | 30.3 (24.8) | |||||

95% CI for IIV/BOV | 8.70–16.0 | 41.8–59.6 | 20.9–35.7 |

↵a Data are for 24 pregnant and 24 nonpregnant women. CL, elimination clearance;

*V*, volume of distribution; MTT, mean absorption transit time; No. of transit comp., number of transit compartments;*F*, oral bioavailability; σ, additive residual error; IIV, interindividual variability; BOV, between-occasion variability.↵b Computed population mean values from NONMEM are calculated for a typical patient with a body weight of 48.5 kg and an initial logarithmic parasitemia of 3.98. Relative standard error (RSE) was assessed by the nonparametric bootstrap method (

*n*= 1,000 iterations, of which 919 minimized successfully) of the final pharmacokinetic model. RSE is calculated as 100 × (standard deviation/mean value). The 95% confidence interval (CI) is displayed as the 2.5 to 97.5 percentile of bootstrap estimates. Coefficient of variation (% CV) for interindividual variability and between-occasion variability are calculated as SQRT of [exp(estimated variance) − 1], where SQRT is the square root.↵c Between-occasion variability.