Group | CL/F (liters/h/kg) | V/F (liters/kg) | t_{1/2} (h) | T_{max} (h) | C_{max} (ng/ml) | AUC_{0-24} (ng · h/ml) |
---|---|---|---|---|---|---|

Total | 2.09 (1.59–2.84) | 3.15 (2.61–4.75) | 1.10 (1.04–1.21) | 1.09 (0.857–1.36) | 464 (300–592) | 1,070 (727–1,330) |

Pregnant | 2.32 (2.00–4.03) | 3.59 (3.04–6.62) | 1.06 (1.02–1.21) | 0.965 (0.813–1.30) | 391 (241–545) | 956 (559–1,110) |

Nonpregnant | 1.72 (1.38–2.27) | 3.03 (2.17–3.48) | 1.16 (1.07–1.21) | 1.24 (0.920–1.41) | 500 (399–715) | 1,210 (1,030–1,530) |

P value | 0.001 | 0.008 | 0.205 | 0.093 | 0.027 | 0.001 |

↵a Data are for 24 pregnant and 24 nonpregnant women. Post hoc estimates were calculated as median values (interquartile ranges) from empirical Bayes estimates, and statistical differences were estimated with a nonparametric Mann-Whitney test. CL, elimination clearance;

*F*, oral bioavailability;*V*, volume of distribution;*t*_{1/2}, terminal elimination half-life;*T*_{max}, predicted time to peak concentration;*C*_{max}, predicted peak concentration; AUC_{0-24}, area under the concentration-time curve from time point 0 to 24 h.