Table 4

Respiratory tract culture results, stratified by voriconazole troughs at the time of culture

Voriconazole trough% of positive cultures (n = 53)a% of total positive cultures (n = 53)a% of negative cultures (n = 104)aP valued
IFIb (n = 10)Colonizationc (n = 43)
≤0.5 μg/ml10 (1/10)23 (10/43)21 (11/53)22 (23/104)1.0
>0.5 μg/ml90 (9/10)77 (33/43)79 (42/53)78 (81/104)
≤1 μg/ml50 (5/10)51 (22/43)51 (27/53)35 (36/104)0.06
>1 μg/ml50 (5/10)49 (21/43)49 (26/53)65 (68/104)
≤1.5 μg/ml60 (6/10)70 (30/43)68 (36/53)46 (48/104)0.01
>1.5 μg/ml40 (4/10)30 (13/43)32 (17/53)54 (56/104)
≤2 μg/ml70 (7/10)72 (31/43)72 (38/53)58 (60/104)NS (0.12)
>2 μg/ml30 (3/10)28 (12/43)28 (15/53)42 (44/104)
  • a The values in parentheses are the number of positive or negative cultures to the total number of cultures.

  • b Anastomotic tracheobronchits was caused by Candida glabrata (n = 3), Candida albicans (n = 2), a yeast species that was not identified to the species level (n = 1), Penicillium (n = 1), Aspergillus niger (n = 1), and an unidentified mold (n = 2).

  • c Colonization was caused by 19 Candida isolates (9 C. glabrata isolates, 6 C. albicans isolates, 2 C. krusei isolates, and one isolate each of C. tropicalis and C. parapsilosis, and 24 mold isolates (9 Penicillium isolates, 6 Aspergillus niger isolates, 2 Fusarium isolates, 2 Rhizopus isolates, 1 Scedosporium isolate, 1 Lecythofora isolate, and 3 unidentified molds). Seven patients were colonized for a single episode, and 18 patients were colonized for two episodes at unique times.

  • d The P values result from a comparison of values for the 53 positive cultures compared to the values for the 104 negative cultures at their respective troughs. NS, not significant.