Table 5

Respiratory tract culture results among 93 patients, stratified by achievement of voriconazole cutoff troughs

Voriconazole troughs (n = 93)% of patients with the following microbiology resulta:P valueb
Positive cultures (n = 35)Negative cultures (n = 58)
No trough > 1 μg/ml (n = 20)65 (13/20)35 (7/20)0.01
At least one trough > 1 μg/ml (n = 73)30 (22/73)70 (51/73)
No trough > 1.5 μg/ml (n = 24)62.5 (15/24)37.5 (9/24)0.007
At least one trough > 1.5 μg/ml (n = 69)29 (20/69)71 (49/69)
  • a The values in parentheses are the number of patients with a positive or negative result to the total number of patients.

  • b The P values result from a comparison of values for the positive cultures compared to the values for the negative cultures.