Table 6

Liver enzyme abnormalities during voriconazole prophylaxis

Grade of toxicity% of patients with the following liver enzyme toxicitya:
118 (17/93)9 (8/93)25 (23/93)b
22 (2/93)2 (2/93)15 (14/93)c
31 (1/93)04 (4/93)d
  • a For aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), liver enzyme toxicity was defined as follows: grade 1, upper limit of normal (ULN) to 2.5× ULN; grade 2, >2.5× to 5× ULN; grade 3, >5× to 20× ULN; grade 4, >20× ULN. At the University of Pittsburgh Medical Center (UPMC), the respective ULN values for AST, ALT, and ALP, are 41 U/liter, 63 U/liter, and 126 U/liter, respectively. The values in parentheses are the number of patients with toxicity to the total number of patients.

  • b One patient also had transaminase toxicity.

  • c Three patients also had transaminase toxicity.

  • d Five patients also had transaminase toxicity.