Table 2

Susceptibility of Propionibacterium acnes rRNA mutants to TP-434 and comparators

AntibioticMIC (μg/ml)a
ATCC 6919 (wild type; Erys Clis Tets)SW101 CDA [erm(X); Eryr Clir Tets]SW101T (23S rRNA A2058G; 16S rRNA G1058C; Eryr Clir Tetr)P:413 (16S rRNA G1058C; Erys Clis Tetr)
TP-4340.063≤0.01611
Tigecycline0.50.522
Tetracycline10.1251616
Doxycycline10.12588
Erythromycin0.125>32320.063
Penicillin≤0.016≤0.016≤0.016≤0.016
  • a Genotypes are as described in reference 15. 23S rRNA A2058G confers MLSB resistance; 16S rRNA G1058C confers tetracycline resistance. Eryr or Erys, erythromycin resistant or sensitive; Clir or Clis, clindamycin resistant or sensitive; Tetr or Tets, tetracycline resistant or sensitive. rRNA base numbering is derived from E. coli.