Table 3

Drug exposure at steady state in serum and kidneys and log reduction of median kidney burden of mice receiving echinocandinsc

Compound and dosagesAUC (mg · h/liter)Log reduction in kidneys
SerumKidneyExperiments 1 to 3aExperiment 4b
S3R83RR24S3R83RR24
Anidulafungin
    High dose (12 mg/kg)556.5812.00.7940.805−0.9820.9011.053ND
    Medium dose (6 mg/kg)278.1406.00.9240.831−0.0970.7170.673ND
    Low dose (3 mg/kg)139.0203.0−0.5150.147−0.1300.3400.522ND
Caspofungin
    High dose (6 mg/kg)786.21091.02.728*1.850*−1.1393.9422.655ND
    Medium dose (3 mg/kg)393.1545.42.517*1.445−0.1763.0672.053ND
    Low dose (1.5 mg/kg)196.6272.71.8780.367−1.1811.8451.372ND
Micafungin
    High dose (12 mg/kg)373.7443.61.431*1.558*0.0211.7471.528ND
    Medium dose (6 mg/kg)186.9221.80.6181.170−0.8541.2431.535ND
    Low dose (3 mg/kg)93.4110.90.4370.7680.0210.7571.462ND
  • a Six animals per group.

  • b Three animals per group. ND, not done.

  • c The echinocandins studied were anidulafungin (3, 6, and 12 mg/kg), caspofungin (1.5, 3, and 6 mg/kg), and micafungin (3, 6, and 12 mg/kg). Negative values indicate higher CFU counts than in untreated control kidneys. S3 indicates C. glabrata wild-type-challenged mice, R83 indicates Fks2p-S663F mutant-challenged mice, and RR24 indicates Fks1p S629P mutant-challenged mice. Significant log reduction is indicated by an asterisk.