Table 3

Susceptibility of TP-434 and comparators to E. coli DH10B expressing recombinant major tetracycline resistance genes

AntibioticMIC (μg/ml) for E. coli strain expressing:
lacZtet(M)tet(K)tet(A)tet(B)tet(X)
TP-4340.0630.0630.0310.250.0634
Tigecycline0.0630.130.06310.0632
Doxycycline2644323216
Minocycline0.56418164
Tetracycline2128128>128>128128
Ceftriaxone0.0630.130.0630.130.130.13