Table 1

In vitro antifungal susceptibility patterns of Scedosporium and Pseudallescheria species against eight antifungal compounds (AMB, CAS, ITC, ISA, VRC, ANI, POS, and MICA)

SpeciesnaMIC and MEC (μg/ml) and GM values
AMBCASANIMICAITCVRCPOSISA
RangeMIC50MIC90GMRangeMEC50MIC90GMRangeMEC50MIC90GMRangeMEC50MEC90GMRangeMIC50MIC90GMRangeMIC50MIC90GMRangeMIC50MIC90GMRangeMIC50MIC90GM
P. apiosperma1540.5–>168>166.80.5–>8181.50.125–>80.580.80.016–>80.12540.20.25–>16>16>1616.20.25–8120.90.25–>161>162.41–>168167.4
P. boydii600.5–>1616>1611.81–>8282.30.25–>8181.40.062–>80.250>80.50.125–>16>16>1613.80.125–2110.70.125–>16141.30.5–>168165.7
S. prolificans378–>16>16>1628.62–>8>8>810.40.5–>84>84.80.125–>8>8>87.9>16–>16>16>1632.04–>1616>1615.4>16–>16>16>1632.08–>16>16>1625.6
S. dehoogii222–>1616>1612.81–>88>87.51–>88>88.30.125–>80.5>81.10.5–>16>16>1616.00.5–>16181.50.5–>161>163.42–>168>168.0
S. aurantiacum2216–>16>16>1628.22–>88>86.81–>88>87.51–>88>86.81–>16>16>1619.30.5–10.510.61–>161>162.74–168166.8
P. ellipsoidea164–>1616>1616.01–2121.20.125–>80.520.60.062–80.1250.2500.12–>16>16>1622.60.5–4120.90.5–>161>163.12–>168>168.4
P. angusta150.5–>168166.91–>84>84.52–>82>82.30.062–>80.5>80.90.25–>16>16>168.30.25–20.520.60.25–>161>161.41–>164164.5
P. minutispora61–4442.81–8283.20.5–4241.60.125–80.25080.40.5–>16>16>1616.00.25–20.520.80.5–>161>161.62–168166.3
  • a n, Number of isolates.