Table 4

Log kill values of different efflux pump KO mutants in the presence and absence of efflux inhibitors

StrainLog kill value (log10 CFU/ml)a
Pyrrole AZI-533AZI-533 + PAβNPyrazolone AZI-219AZI-219 + verapamil
WT Mtuc0.61.701.4
KO111.300.9
KO51.91.63.5>3.5b
KO60.81.201.8
KO72.12.40.63.1
  • a Log kill values for WT M. tuberculosis and the different efflux pump KO mutants at the highest concentration of the compounds tested.

  • b Below the LOQ (limit of quantification).

  • c M. tuberculosis.