Table 1

MIC, mean FIC, and interaction between FLC and AMB against 14 C. gattii strains

C. gattii strain or parameteraMIC (μg/ml)bMean FIC (μg/ml)Interaction
FLC (50%)FLC (80%)AMB
ATCC 240652.04.00.061.19Indc
ATCC 326088.016.00.061.45Ind
L135/03 (C)8.016.00.061.90Ind
L28/02 (C)16.032.00.062.18Ind
23/10993 (C)8.016.00.1251.71Ind
196L/03 (C)16.032.00.062.52Ind
1913 ER (C)8.016.00.1251.42Ind
547/OTTI/94-PI-10 (E)32.032.00.061.93Ind
L27/01 (C)32.032.00.062.06Ind
LMM 818 (C)16.032.00.1251.49Ind
29/10893 (C)8.08.00.1251.07Ind
L24/01 (C)8.016.00.062.66Ind
ICB 133 (E)8.016.00.1250.77Ind
ICB 181 (E)8.016.00.061.45Ind
MIC508.016.00.06
MIC9032.032.00.125
MIC range2.0–32.04.0–32.00.06–0.125
Geometric mean10.2518.220.0791.61Ind
  • a C, clinical strain; E, environmental strain.

  • b The MIC is given except as noted otherwise in column 1. MIC (50%), MIC endpoint considering 50% of growth inhibition (6); MIC (80%), MIC endpoint considering 80% of growth inhibition (19). FLC, fluconazole.

  • c Ind, indifferent.