Table 1

Bacterial numbers in lungs and spleens 1 day postinfection, 12 days postinfection (start of drug treatment), and after 2, 4, 6, and 8 weeks of treatment in BALB/c mice

Treatment period and regimenLung lobeaSpleena
Log10 CFU ± SEMNo. of mice with CFU/totalLog10 CFU ± SEMNo. of mice with CFU/total
Day 14.04 ± 0.065/5
Day 12 (pretreatment controls)7.47 ± 0.065/53.65 ± 0.205/5
Day 178.24 ± 0.147/75.36 ± 0.127/7
Day 268.30 ± 0.702/25.65 ± 0.132/2
2 wk
    INH5.50 ± 0.085/51.94 ± 0.242/5
    RIF5.11 ± 0.115/52.49 ± 0.244/5
    LIN5.55 ± 0.085/54.21 ± 0.125/5
    PZA6.11 ± 0.001/5b4.50 ± 0.135/5
    MET8.13 ± 0.407/75.23 ± 0.097/7
4 wk
    INH4.98 ± 0.035/50.00 ± 0.000/5
    RIF4.56 ± 0.085/51.90 ± 0.103/5
    LIN5.18 ± 0.125/54.14 ± 0.135/5
    PZA5.58 ± 0.075/54.82 ± 0.105/5
6 wk
    INH4.56 ± 0.095/50.00 ± 0.000/5
    RIF3.31 ± 0.025/50.00 ± 0.000/5
    LIN4.03 ± 0.065/53.77 ± 0.125/5
    PZA5.28 ± 0.075/54.99 ± 0.095/5
8 wk
    INH3.62 ± 0.065/50.00 ± 0.000/5
    RIF3.36 ± 0.295/50.34 ± 0.341/5
    LIN3.71 ± 0.164/53.70 ± 0.174/5
    PZA5.51 ± 0.095/55.15 ± 0.105/5
  • a Data are mean ± standard error of the mean (SEM) log10 CFU counts in the lung and spleen and the number of mice that yielded CFU data over the total number of mice in that group.

  • b Only one mouse yielded viable colonies due to technician error.