Table 2

Bacterial numbers in lungs and spleens 1 day postinfection, 42 days postinfection (start of drug treatment), and after 2, 4, and 7 weeks of treatment in Kramnik mice

Treatment period and regimenLung lobeaSpleena
Log10 CFU ± SEMNo. of mice with CFU/totalLog10 CFU ± SEMNo. of mice with CFU/total
Day 11.57 ± 0.215/5
Day 42 (pretreatment controls)6.85 ± 0.445/54.48 ± 0.064/5
2 wk
    Control6.77 ± 0.415/54.57 ± 0.115/5
    INH5.52 ± 0.545/52.82 ± 0.095/5
    RIF5.31 ± 0.195/53.30 ± 0.235/5
    LIN6.24 ± 0.315/54.10 ± 0.125/5
    PZA6.53 ± 0.395/54.41 ± 0.245/5
    MET6.35 ± 0.395/54.52 ± 0.145/5
4 wk
    Control7.25 ± 0.465/54.94 ± 0.135/5
    INH5.43 ± 0.625/54.08 ± 0.165/5
    RIF4.82 ± 0.615/52.68 ± 0.185/5
    LIN5.68 ± 0.465/53.95 ± 0.265/5
    PZA6.74 ± 0.715/54.40 ± 0.295/5
    MET7.58 ± 0.455/54.67 ± 0.185/5
7 wk
    Control7.98 ± 0.274/45.46 ± 0.214/4
    INH6.22 ± 1.613/51.95 ± 0.494/5
    RIF5.13 ± 0.484/50.79 ± 0.492/5
    LIN4.97 ± 0.689/93.44 ± 0.369/9
    PZA6.57 ± 0.449/94.36 ± 0.219/9
    MET7.50 ± 0.425/54.86 ± 0.125/5
  • a Data are log10 CFU counts in the lung and spleen and the number of mice that yielded CFU data over the total number of mice in that group.