Table 3

Numbers of drug-susceptible and drug-resistant bacterial colonies isolated from lungsa

Mouse group and treatment regimenaLung datab
CFU ± SEMNo. of mice with CFU/total
BALB/c mice
    Start of treatment7.47 ± 0.065/5
    6 wk, INH, 7H114.89 ± 0.095/5
    6 wk, INH, R0.5 ± 0.51/5*
    8 wk, INH, 7H113.99 ± 0.075/5
    8 wk, INH, R0.5 ± 0.51/5*
    6 wk, RIF, 7H113.53 ± 0.065/5
    6 wk, RIF, R0 ± 00/5
    8 wk, RIF, 7H113.37 ± 0.245/5
    8 wk, RIF, R0.99 ± 0.612/5*
    6 wk, LZD, 7H114.41 ± 0.075/5
    6 wk, LZD, R0 ± 00/5
    8 wk, LZD, 7H114.24 ± 0.075/5
    8 wk, LZD, R0.68 ± 0.681/5‡
Kramnik mice
    Start of treatment6.85 ± 0.445/5
    4 wk, control, 7H117.58 ± 0.425/5
    7 wk, control, 7H118.26 ± 0.524/4
    4 wk, INH, 7H114.91 ± 0.675/5
    4 wk, INH, R1.26 ± 1.261/5†
    7 wk, INH, 7H115.72 ± 1.115/5
    7 wk, INH, R4.47 ± 1.833/5
    4 wk, RIF, 7H114.39 ± 0.645/5
    4 wk, RIF, R0 ± 00/5
    7 wk, RIF, 7H115.47 ± 0.684/4
    7 wk, RIF, R3.57 ± 1.263/4
    4 wk, LZD, 7H115.47 ± 0.465/5
    4 wk, LZD, R0 ± 00/5
    7 wk, LZD, 7H114.96 ± 0.945/5
    7 wk, LZD, R0 ± 00/5
  • a R, resistant colonies.

  • b The data shown are log10 CFU counts in the lung and the number of mice that yielded CFU data over the total number of mice that group. Right upper lung lobes were plated on 7H11 plates with and without drugs (INH, 4 mg/ml; RIF, 0.4 mg/ml; and LZD, 8 mg/ml). For the last two treatment time points for both BALB/c and Kramnik models, lobes were plated on drug-containing plates.

  • * , only 1 colony per mouse detected; †, 1 mouse with a high number of colonies, a potential outlier; ‡, 1 mouse with 8 colonies.