Table 3

Evaluation of the antimicrobial activities of drug combinations against intracellular bacteria in bone marrow-derived macrophages

Species and agentsNo. (%) of isolates with combination activitya
SynergismIndifferenceAntagonism
M. abscessus (n = 15)
    CLR-MXF1 (6.6)4 (26.7)10 (66.7)
    AZM-MXF1 (6.6)8 (53.3)6 (40.0)
M. massiliense (n = 15)
    CLR-MXF5 (33.3)9 (60.0)1 (6.7)
    AZM-MXF3 (20.0)10 (66.7)2 (13.3)
  • a The effects of antibiotic combinations were determined by adopting the x/y quotient method. Synergism, an x/y value of ≤0.5; indifference, a value of >0.5 and <2.0; antagonism, a value of ≥2.0.