Table 2

In vitro antimicrobial activities of the combinations of a macrolide and moxifloxacin against M. abscessus and M. massiliense

Species and agentsNo. (%) of isolates with combination activitya
SynergismIndifferenceAntagonism
M. abscessus (n = 26)
    CLR-MXF1 (3.8)8 (30.8)17 (65.4)
    AZM-MXF1 (3.8)13 (50.0)12 (46.2)
M. massiliense (n = 28)
    CLR-MXF11 (39.3)16 (57.1)1 (3.6)
    AZM-MXF10 (35.7)16 (57.1)2 (7.1)
  • a The effects of antibiotic combinations were determined by the fractional inhibitory concentration (FIC): synergism, FIC index of ≤0.5; indifference, FIC index of >0.5 and <2.0; antagonism, FIC index of ≥2.0.