Table 1

Summary of IC50 data for the use of harmine and a partner drug in combination against Plasmodium falciparum CQ-susceptible strain 3D7a

Harmine IC50 (μM)Partner drugbPartner drug IC50 (μM)ΣFIC50
5.17E−03ART2.90E−070.10
1.34E−04CQ6.04E−050.08
7.58E−02ACR1.40E−040.75
  • a In all experiments, harmine was used at a concentration of 1.25 pM and the partner drug was used at a concentration of 0.125 pM.

  • b Abbreviations for the partner drugs used in the combination treatments: CQ, chloroquine; ART, artemisinin; ACR, acrisorcin.