Table 1

Development of the RAMs in the PR coding region from 1998 to 2009

Sampling date (mo/yr)Changes from the HIV-1 subtype B and AG amino acidsa
Subtype BT4L10T12I13K14K20A22L33E35M36N37R41K43G48I54I6 6H69A71T74T80V82N83I84L89L90T91L97
Subtype AGVVK/RIRILKKM
4/98nVnnInVnInnnnnnnnnnnn
3/00VARIIDIDKRVFKSIM
6/02SIARIVIDIDKSAVFKSAVIMSI
9/02SIARIVIDIDKSAVFKSAVIMSI
11/02SIARIVIDIDKSAVFKSP/TAN/HVIMSI
12/02SIARIVIDIDKSAVFKSA/VVIM/LSI
1/03SVARIVIDIDKSAVFKSAVIMSI
2/03SVARIVIDIDKSAVFKSAVIMS
5/03SIARIVIDIDKSAVFKSAVIMS
6/03SIARIVIDIDKSAVFKSAVIMS
7/03SIARIVIDIDKSAVFKSAVIMS
9/03SIARIVIDIDKSAVFKVSAVIMS
1/04SIARIVIDIDKSAVFKVSAD/NVVMS
5/04SIARIVIDIDKSAVFKVSAVVMS
6/04SIARIVIDIDKSAVFKVSAVVMS
11/04SIARIVIDIDKSAVFKVSAVVM/TS
4/05SIARIVIDIDKSAVFKVSAVVMS
10/06SVI/M/TARIVIDIDKSAVFKVSAVVMS
7/08SIARIVIDIDKSAVFKVSAVVMS
12/08SVARIVIDIDKSAVFKAVSAVIVMS
2/09SIITAIVIDIDKSAVFKAVSAVIVMS
3/09SIARIVIDIDKSAVFKSAVIMS
4/09SIARIVIDIDKSAVFKSAVMS
5/09SIARIVVDIDKSAVFKSAVMS
  • a Amino acid residue changes compared to HIV-1 subtypes B and AG are indicated. RAMs are underlined, and subtype AG-specific polymorphisms are depicted in boldface letters. n, not determined due to quality problems.