Table 3

Sequence determination of the patient-derived PR cleavage sitea

Cleavage siteSequence of the PR cleavage site from:
Subtype BSubtype CRF02_AGPatientb
MA/CAVSQNY/PIVQNVSQNY/PIVQNSSQNY/PIVQN
CA/p2KARVL/AEAMSKARVL/AEAMSKARVL/AEAMS
p2/NCPATIM/IQKGNQAGVM/MQRSNQANVM/IQRGN
NC/p1ERQAN/FLGKIERQAN/FLGRIVRQAD/FLGRI
p1/p6RPGNF/LQSRPRPGNF/PQSRPRPGNF/PQSRI
p6pol/PRVSFSF/PQITLPSFSF/PQITLISLNC/PQISL
PR/RTp51CTLNF/PISPICTLNF/PISPICTLNF/PISPI
RT/RTp66GAETF/YVDGAGAETF/YVDGAGAETF/YVDGA
RT/INIRKVL/FLDGIVRKVL/FLDGIIRKVL/FLDGI
  • a Slashes indicate the position of the cleavage sites.

  • b The protease was taken from the patient in November 2004. The cleavage site sequences were determined from 3 independent clones. Amino acid changes between the subtype CR02_AG and the patient-derived sequences are underlined.