Table 1

Compound structures and activities

Table 1
  • a Concentration (μM) required to inhibit in vitro protein-protein interaction by 50%.

  • b Effective concentration (μM) required to reduce HIV-1-induced cytopathic effect by 50% in MT-4 cells.

  • c Effective concentration (μM) required to reduce HIV-1-induced cytopathic effect by 90% in MT-4 cells.

  • d Cytotoxic concentration (μM) reducing MT-4 cell viability by 50%.

  • e Selectivity index: ratio, CC50/EC50. The averages and standard deviations for at least 3 independent experiments are shown.

  • f Identical with compound 6 in reference 23.

  • g Identical with compound 7 in reference 23.