Table 1

Susceptibility profile, sequence types, and PFGE patterns for 34 KPC-2-producing K. pneumoniae isolates from Brazil

STPFGE pattern(s)No. of isolatesLocation(s)bMIC range (μg/ml) (no. of resistant isolates/total no. of isolates)a
P/TCAZCROFEPAZTERTIMIMERCIPGENTPOLB
ST11A, C, E, F, G, I10São Paulo, SP; Porto Alegre, RS; Recife, PE; Belo Horizonte, MG; Brasília, DF64–256 (10/10)16–256 (10/10)64–>256 (10/10)64–>256 (10/10)128–>256 (10/10)8–256 (10/10)2–64 (8/10)1–64 (9/10)4–>32 (10/10)0.5–256 (5/10)1–64 (1/10)
ST17H1Campo Grande, MS256 (1/1)16 (1/1)16 (1/1)8 (0/1)128 (1/1)4 (1/1)1 (0/1)2 (0/1)4 (1/1)0.5 (0/1)32 (1/1)
ST70B2João Pessoa, PB128 (2/2)8 (0/2)8–16 (2/2)2–4 (0/2)16–64 (2/2)2 (2/2)0.5 (0/2)1 (0/2)1 (0/2)0.5 (0/2)1 (0/2)
ST133A1São Paulo, SP128 (1/1)8 (0/1)8 (1/1)64 (1/1)>256 (1/1)8 (1/1)≤1 (0/1)≤1 (0/1)≤0.25 (0/1)1 (0/1)4 (0/1)
ST340A1São Paulo, SP128 (1/1)128 (1/1)256 (1/1)64 (1/1)256 (1/1)8 (1/1)1 (0/1)2 (0/1)32 (1/1)128 (1/1)1 (0/1)
ST437A18João Pessoa, PB; São Paulo, SP64–256 (17/18)8–>256 (17/18)32–>256 (18/18)8–>256 (17/18)128–>256 (18/18)4–>256 (18/18)≤0.25–64 (6/18)≤0.5–64 (7/18)32–>256 (18/18)0.5–128 (4/18)1–64 (2/18)
ST617D1São Paulo, SP256 (1/1)16 (1/1)32 (1/1)16 (0/1)128 (1/1)4 (1/1)0.5 (0/1)2 (0/1)0.25 (0/1)0.5 (0/1)1 (0/1)
Total % resistance94.188.210085.310010041.247.188.229.411.8
  • a P/T, piperacillin-tazobactam; CAZ, ceftazidime; CRO, ceftriaxone; FEP, cefepime; AZT, aztreonam; ERT, ertapenem; IMI, imipenem; MER, meropenem; CIP, ciprofloxacin; GENT, gentamicin; and POLB, polymyxin B.

  • b DF, Distrito Federal; MG, Minas Gerais; MS, Mato Grosso do Sul; PB, Paraíba; PE, Pernambuco; RS, Rio Grande do Sul; and SP, São Paulo.