Table 6

Susceptibility profiles of K. pneumoniae strains after complementation with pACoqxRa

StrainMICs (mg/liter) for strain transformed with pACoqxR/paCYC177
CHLOQXTETTIGNORCIP
GC964/64768/76816/164/48/88/8
GC1224/24768/76816/168/88/812/12
GC19256/256768/76832/324/44/41/1
GC2124/24768/76816/168/88/812/12
Kp34248/64384/51232/328/84/80.375/0.500
Ecl8Mdr132/32384/5124/41/18/80.500/0.500
  • a MICs show values for strains complemented with pACoqxR/strains complemented with pACYC177. Numbers in bold indicate MIC reductions seen with the complemented strain versus the vector-only control. CHL, chloramphenicol, OQX, olaquindox, TET, tetracycline, TIG, tigecycline, NOR, norfloxacin, CIP, ciprofloxacin.