Table 1

MIC and QPCR measurements of tigecycline mutants (TGC1, TGC3, and TGC5)

StrainMICaFold expression increase vs Ecl8ΔramA
NORCIPTETOQXTIGrarAoqxAmarAacrB
Ecl80.2500.0314162
Ecl8ΔramA0.0630.016281
TGC180.251632164.596.066.0655.72
TGC380.25832817.1513.9312.13103.97
TGC580.2581682.143.035.2827.86
  • a NOR, norfloxacin; CIP, ciprofloxacin; TET, tetracycline; OQX, olaquindox; TIG, tigecyline.