Table 2

S. aureus strains tested and MICs

StrainaMIC (μg/ml)
DaptomycinFosfomycinVancomycin
MSSA 11120.581
MSSA P30.541
MSSA P40.581
MSSA P70.581
MSSA 42970.511
MSSA RN42200.540.5
MSSA 678181
MRSA 2770.2542
MRSA P80.541
MRSA 21670.5162
MRSA 41940.2581
MRSA 7260.25160.5
GISA PC3288
GISA ATCC 7007880.5168
  • a All isolates were stored at −80°C in skim milk prior to testing. Daptomycin susceptibility testing was performed in Mueller-Hinton broth (MHB) adjusted to 50 μg/ml calcium in accordance with the standard methodology. Fosfomycin susceptibility testing was performed in MHB supplemented with 25 μg/ml glucose-6-phosphate in accordance with the standard methodology. S. aureus ATCC 29213 was used as the control strain. MSSA RN4220, GISA PC3, and GISA ATCC 700788 were used as reference strains. The remaining 11 strains were isolated from the blood of patients with S. aureus endocarditis (1 isolate per patient). MSSA 678 was from case 1, and MRSA 726 was from case 3 (see Table 1).