Table 1

Microbiological characteristics of Klebsiella pneumoniae and Escherichia coli isolates recovered before and after a tigecycline-containing regimen

IsolateaSourceβ-Lactamase geneDL typebMICc (mg/liter)
AMKGENAMCFEPCTXCAZTZPERTIPMMEMLVXSXTCSTTGC
P1-KP1UrineSHV-12A≤2≥32≥32>648>64>1280.120.120.03≤0.12≥3200.50.5
P1-KP2UrineSHV-12A≤2≥32≥32>648>64>1280.120.120.03≤0.12≥3200.516
P2-EC1Liver aspirateKPC-3B16≥32≥32>64>64>64>128>3248≥8≥3200.50.5
P2-EC2BloodKPC-3B16≥32≥32>64>64>64>128>3248≥8≥3200.50.5
P2-EC3Rectal swabKPC-3B16≥32≥32>64>64>64>128>3248≥8≥3200.50.5
P2-KP1Rectal swabKPC-3C≥644≥32>64>64>64>128>32>32>32≥8≥320≥160.5
P2-KP2UrineKPC-3C≥644≥32>64>64>64>128>32>32>32≥8≥320≥160.5
P2-KP3BloodKPC-3C≥644≥32>64>64>64>128>32>32>32≥8≥320≥160.5
P2-EC4BloodKPC-3B≥64≥32≥32>64>64>64>128>32>32>32≥8≥3200.524
P2-EC5Liver aspirateKPC-3B≥64≥32≥32>64>64>64>128>32>32>32≥8≥3200.524
P2-KP4BloodKPC-3C≥644≥32>64>64>64>128>32>32>32≥8≥320≥160.5
  • a P1-KP, patient 1 K. pneumoniae isolates recovered before (KP1) or after (KP2) a tigecycline-containing regime; P2-EC, patient 2 E. coli isolates recovered before (EC1 to -3) or after (EC4 and -5) a tigecycline-containing regimen; P2-KP1 to -4, patient 2 K. pneumoniae.

  • b DL, DiversiLab microbial typing system.

  • c AMK, amikacin; GEN, gentamicin; AMC, amoxicillin-clavulanate; ERT, ertapenem; LVX, levofloxacin; SXT, trimethoprim-sulfamethoxazole; FEP, cefepime; CTX, cefotaxime; CAZ, ceftazidime; IPM, imipenem; MEM, meropenem; TZP, piperacillin-tazobactam; CST, colistin; TGC, tigecycline.