Table 2

MIC and AK measures of bacterial species and antibiotic combinationsa

Strain and parameterTreatment (× MIC)Value for agent
BactericidalBacteriostatic
AmpicillinCeftriaxoneCiprofloxacinVancomycinMeropenemColistinSulfamethoxazoleMinocyclineErythromycinKanamycinLinezolid
Enterococcus faecium 824-05
    MIC>256>2562562>256>256>2561>256>25616
    Fold increase in AK signal0.5NDNDND1NDNDND3NDND2
1.0NDNDND2NDNDND4NDND2
Staphylococcus aureus
    USA300-0114
        MIC>256>256214>256>256164>2562
        Fold increase in AK signal0.5NDND31113NDND11ND1
1.0NDND5317NDND11ND1
    RN4220
        MIC22222>256282162
        Fold increase in AK signal0.54108311ND21111
1.031210611ND31111
Klebsiella pneumoniae cKP1
    MIC>2562>256>25628>25664>2562>256
    Fold increase in AK signal0.5ND50NDND12834ND1ND1ND
1.0ND55NDND22033ND1ND1ND
Acinetobacter baumannii 98-37-09
    MIC25680.0625642481162256
    Fold increase in AK signal0.5ND522791762333ND
1.0ND2124134495141214ND
Pseudomonas aeruginosa PA01
    MIC>25642>256242563232256>256
    Fold increase in AK signal0.5ND227ND455ND13NDND
1.0ND14182ND3912ND61NDND
Enterobacter cloacae PMD1001
    MIC>2562<1>25622>25642562>256
    Fold increase in AK signal0.5ND206ND9910ND4ND1ND
1.0ND177ND29632ND9ND1ND
Escherichia coli 8295
    MIC12820.1251628>2561625632>256
    Fold increase in AK signal0.550511716015ND4ND55ND
1.074763928522ND38ND70ND
% increase expected0.510083.383.340100100505050400
1.010010083.36010010010062.525400
  • a Shading indicates significant increase in AK signal (greater than or equal to threefold over vehicle-treated cells).