Table 4

Typical estimates of exposure parameters and clearance of anidulafungin in patients with different demographics following a 200/100-mg regimen at 1-mg/min infusion rate

ParameterValue by patient gender and wt (kg)
MaleFemale
40601504060150
Study 1 (EC)
    Cmax, ss (mg/liter)7.97.04.69.07.95.0
    Cmin, ss (mg/liter)3.43.12.24.54.02.6
    AUCss (mg · h/liter)1151047314612984
    CL (liters/h)0.870.961.40.680.781.2
Study 2 (ICC)
    Cmax, ss (mg/liter)6.96.14.27.66.74.5
    Cmin, ss (mg/liter)2.32.21.73.02.82.0
    AUCss (mg · h/liter)8982611069769
    CL (liters/h)1.11.21.60.941.01.5