Table 6

Model-building steps (ENDF-AUC in study 1)

Patient group (na) and run no.DescriptionOFVParameter estimate (% RSE)
θ1θ2θ3
All treated EC patients (129)
    1θ11730.425 (42)
    2θ1 + θ2 × AUC172−0.162 (433)0.00937 (116)
    3θ1 × (age/38)θ3 + θ2 × AUC171−0.285 (122)0.0121 (52)−2 (80)
    4θ1 × θ3sex + θ2 × AUC172−0.126 (717)0.00901 (138)1.22 (366)
Clinical evaluable EC patients (102)
    5θ11220.923 (24)
    6θ1 + θ2 × AUC1210.168 (490)0.012 (106)
    7θ1 × (age/38)θ3 + θ2 × AUC1200.37 (162)0.00887 (108)1.21 (87)
  • a n, no. of patients.