Table 3

Ratio of noncompartmental PK analysis parameter estimates after multiple doses to those after single doses for fusidic acid by cohort for study 103a

CohortDose (mg)Geometric mean (% CV) ratio of PK parameter estimate for multiple to single doses
CmaxAUC0–12 hAUCDoset1/2CLT/F
1 (n = 6)5503.35 (28)3.99 (26)2.35 (21)0.663 (36)b0.426 (23)
2 (n = 6)1,1003.86 (13)4.43 (12)2.32 (15)0.945 (33)0.432 (17)
3 (n = 5)1,6503.33 (30)4.40 (26)2.19 (46)1.80 (65)0.457 (36)
  • a See Table 2 for abbreviations.

  • b The median ratio was 0.791.